LC–MS Based Detection of Differential Protein Expression
نویسندگان
چکیده
منابع مشابه
LC-MS Based Detection of Differential Protein Expression.
While several techniques are available in proteomics, LC-MS based analysis of complex protein/peptide mixtures has turned out to be a mainstream analytical technique for quantitative proteomics. Significant technical advances at both sample preparation/separation and mass spectrometry levels have revolutionized comprehensive proteome analysis. Moreover, automation and robotics for sample handli...
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In proteomic studies, liquid chromatography coupled with mass spectrometry (LC-MS) is a common platform to compare the abundance of various peptides that characterize particular proteins in biological samples. Each LC-MS run generates data consisting of thousands of peak intensities for peptides represented by retention time (RT) and mass-to-charge ratio (m/z) values. In label-free differential...
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ژورنال
عنوان ژورنال: Journal of Proteomics & Bioinformatics
سال: 2009
ISSN: 0974-276X
DOI: 10.4172/jpb.1000102